Earlier that day, Lionel Messi departed after France knocked out Argentina 4-3 in Round of 16 match.
"It's not just in this World Cup that they have not been conceding goals".
But the rugged and courageous Godin, who needed reconstructive dental surgery after having three teeth punched out in an aerial challenge with Valencia's goalkeeper earlier this year, has succeeded in muzzling Ronaldo on plenty other occasions at club level going back nearly a decade.
Uruguay won all three of their group matches, beating hosts Russian Federation 3-0 in their last outing, and are the only team yet to concede a goal at the tournament.
Selecao threw on Ricardo Queresma and Andre Silva as they pushed for an equaliser, while Uruguay were dealt a blow when Cavani was forced off with 15 minutes.
Messi's return in Russian Federation was more meagre - at times he looked disillusioned on the field as Argentine struggled to find anything like their usual style and he drifted deep into midfield in the forlorn hope of influencing games.
The Paris Saint-Germain striker had already bagged a brace in the contest, putting Uruguay up 2-1, but was unable to continue in the 74th minute as he limped off the field with the assistance of Cristiano Ronaldo.
EARLY GOAL It was a five-pass build-up from deep in its own end that culminated in Uruguay's first goal, and the final two passes were ideal.
Edinson Cavani's early opener from a superb Luis Suarez cross put La Celeste in the driving seat, enabling them to sit back and soak up the Portuguese pressure. Cavani continued his run and Suarez curled the pass to the back post while Portugal defender Raphael Guerreiro was watching. Suarez makes a brilliant cross from the left for Cavani to head the ball past the goalkeeper.
"Everybody can see that in this World Cup there are no easy games", Alves said.
Stopping Ronaldo. It was that simple for Uruguay.
Uruguay have not exactly set this tournament alight with their attacking play either, but they are more adventurous and have a few more ideas when they come forward.
2 minute: Free-kick to Portugal after Pepe goes down in a challenge from Cavani.