The stars of the teen romance Love Simon, which was heralded as the first major studio release centering on a gay teen, won the award for best kiss.
Zendaya turned heads in a multi-tier, off-the-shoulder red tulle gown with gold heels and matching circular earrings.
FYI: Zendaya is wearing Carolina Herrera. "Kid, I love you more than anything in the world". The British teenager, who deleted her Twitter account last week after a slew of hate-filled comments, used her acceptance speech to speak out against bullying.
Haddish also received an award for Best Comedic Performance for her breakout turn in Girls Trip.
Brown was stuck at home recovering from an injury, but sent a video message to her fans that began, "It's no secret that landing the role of Eleven in "Stranger Things" has changed my life in the most incredible ways".
While his co-star was the best villain, Chadwick Boseman accepted the award for best hero and best performance in a film for playing T'Challa in Black Panther.
"This is gonna live at your house", he said, handing Shaw the award as the crowd gave him a standing ovation.
Back in April, Shaw Jr. was hailed as a hero after saving lives by disarming a gunman, identified by police as Travis Reinking, who opened fire at a Waffle House in Nashville, Tennessee. Host Tiffany Haddish jumped right into the scenes of some of the latest and greatest movies for some parody antics, including Black Panther itself and Star Wars: The Last Jedi.
Netflix's "Stranger Things" was the night's top TV victor, taking home three awards, including a repeat win for best show.
To accept the "Love, Simon" win in the best kiss category, Keiynan Lonsdale - one half of the winning couple alongside Nick Robinson - wore a white skirt and third-eye forehead makeup onstage to deliver a speech inspired by the film's same-sex love story. "So listen up. This is what I call nine rules from Chris Pratt, Generation Award victor".
Common, left, presented actor, writer and showrunner Lena Waithe with an MTV Trailblazer Award.
Keeping up with the Kardashians won Best Reality Series.