Four days after that appearance, the White House announced that the 48-year-old first lady had successfully undergone an "embolisation" procedure to treat a benign kidney condition, and that there were no complications.
Wild theories have circulated online, including that Mrs Trump has moved back to NY with their son, Barron, or that she is co-operating with special counsel Robert Mueller.
But her five-day hospital stay for what was described as relatively minor surgery did little to stop tongues wagging.
Nonetheless, she outshone the President, and the French President and first lady, in late-April, wearing a scene-stealing white hat to an official South Lawn arrival ceremony, garnering comparisons to Beyoncé.
It is clear from her actions that Melania is very much an independent First Lady, not always by her husband's side and even taking five months to move into the White House.
The off-tone tweet caused some Twitter users to worry about the first lady's welfare and demand answers to why she hasn't been seen in weeks.
No word on when she will attend her next public event.
The first lady was last seen on May 10, according to a report by InStyle. Some doctors familiar with the procedure but not involved in her care said people treated with embolization typically are sent home the same day or the next.
"She's doing great. She's looking at us, right there", the president reportedly said, pointing to a window. Trump watched from the audience.
Grisham said the first lady would like to be "out and about promoting her initiatives" but "her health comes first".
They say she feels people are being nosey, rather than genuinely concerned about her, and that she has no desire to reveal any information as a result.