If all stick to that position at Monday's 5 p.m. ET vote, the nomination will not have enough support to be reported favorably to the full Senate.
At the same time, progressives are lighting up phone lines ahead of a crucial vote Monday at the Senate Foreign Relations Committee, where Pompeo faces nearly unified opposition from Democrats.
He could receive an unfavorable recommendation, which according to the Senate historian's office has never happened for a secretary of state nominee before.
"I realize my Democratic friends in many cases feel like that in supporting Pompeo, it's a proxy for support of the Trump administration policies, which many of them abhor", Corker said.
Unlike his fired predecessor, Mr Rex Tillerson, Mr Pompeo can be expected to convey the President's messages to the world, and he may be able to get Mr Trump to heed sometimes unwelcome messages from other world leaders and lawmakers. "He will be a great Secretary of State!"
"I don't expect diplomacy to be negotiated out in the open, but I do expect for someone who is the nominee to be secretary of state, when he speaks with committee leadership and is asked specific questions about North Korea, to share some insights about such a visit", Menendez recently said.
Paul, the libertarian-leaning senator from Kentucky, was the only Republican to vote against Pompeo during his Central Intelligence Agency confirmation hearing. "I understand that", said Sen.
The chairman of the committee, Republican Sen. He has since become one of Trump's most trusted advisers.
As the nomination moves to the Senate floor, the GOP's slim majority, which slips with the absence of Sen.
"Democrats, especially on the Foreign Relations Committee, are really engaged in shameful political behavior, ' Cotton said Sunday on CBS" 'Face the Nation'.
"The most important thing for a secretary of state is to be perceived as speaking for the President", said Dr Jon Alterman, a senior vice-president at the Centre for Strategic and International Studies who was a State Department official under President George W. Bush. Heidi Heitkamp as Democrats who have to publicly announced their support for Pompeo.
The Trump factor hasn't been the only sticking point for Democrats, who have argued that Pompeo's previous statements regarding Muslims and LGBT rights and his hawkish views should disqualify him from serving in a key diplomatic role.