The Bayern Munich midfielder believes Messi is one of the determining factors within the Barca and Jorge Sampaoli's side but there's more to Argentina than Lionel Messi. You have to learn how to go with them, not even in coaching terms, but in the sense of how to bring harmony to him, surrounding him with the right atmosphere.
"As for the team, we are watching [Manuel] Lanzini's progression to see if he can play. We never, at any point, think about risking him".
Spain will host Argentina in the first worldwide to be played at Atletico Madrid's new Wanda Metropolitano stadium with both countries preparing for this year's World Cup in Russian Federation.
Sampaoli insisted he was not gambling over his captain's fitness by fielding Messi against Spain.
And despite training with Argentina he is going to be given time off to recover with the World Cup coming up this summer. It's always special to play against him, " De Gea added.
"I think it's a attractive fixture against Argentina, in an fantastic stadium, and against the runners-up of the World Cup, and where one of the best players in the history of football will be playing", he said.
Spain boss Julen Lopetegui, unbeaten in the position since replacing Vicente del Bosque after Euro 2016, says whether Messi features or not will have little bearing on his team selection.
"It's more hard for us to play there, I don't often go out to the left".
"When we're preparing for a game we're not thinking about what's in front of us", Lopetegui said.
Argentina count on players such as Atletico's Angel Correa, while Ever Banega is at Sevilla and Gonzalo Higuain spent several seasons with Real Madrid.