"Of course it's tough for him because he still doesn't feel in the way he needs to feel", said Pochettino.
Prior to that, Alderweireld played in the 2-0 win over Newport - also in the FA Cup - having not played since the thrilling 3-1 win over Real Madrid on November 1.
Spurs visit Swansea City in the quarter-finals of the FA Cup on Saturday and Pochettino said the competition had become a top priority as it represented the team's only hope of winning a trophy this season.
"He would put his leg in a washing machine to try to score because he's so fearless", he said. "This is the only option we have to try and achieve that", he added. "But he's a warrior, that's why Harry Kane is Harry Kane". We want to help him recover as soon as possible from his injury, that's the first step, to be fully recovered from the injury.
When Kane was injured twice with the same problem last season, he missed seven weeks from September, then just over three weeks from March.
"For me the most important thing is how you're going to use the space in every single game, trying to defeat the different tactics that the opponent is going to use".
The Argentinian manager is said to have called Malcom personally over that time too in order to discuss a potential transfer in the summer.
"The reality is now he's in his crutches and a boot and we need to assess him day-by-day and we'll see the reaction".
"Tottenham in the last few years have shown unbelievable quality and played good football", Pochettino said ahead of Saturday lunchtime's visit to the Liberty Stadium. That is part of the process.