The Massachusetts Democrat has been under increased pressure to provide evidence of her Native American roots, with President Trump repeatedly mocking her as "Pocahontas" as recently as Saturday.
Asked by CNN if she gets upset by Trump's nickname, Warren says she would use his attacks as a chance to lift up the stories of Native Americans.
Last week, an editorial in the Berkshire Eagle called on the senior senator from MA to take a DNA test to finally put the issue to rest, stating she has "nothing to lose but her Achilles' heel".
Some on the left and right are calling on Senator Elizabeth Warren to take a DNA test to straighten out questions about Native American heritage; radio host Howie Carr weighs in. "It's a part of me, and nobody's going to take that part of me away". "It's about my family's story because my family's story is deeply apart of me and apart of my brothers".
"My mother and daddy were born and raised in Oklahoma", Warren said.
Later on Sunday, Warren repeated her defense nearly verbatim when Berkshire Eagle editorial and the subject of her ancestry were again brought up during on interview on Fox News Sunday.
"This is a group that is being injured every single day", Warren said.
Warren responded with the story she said she had been told by family members about her parents - that her father's family didn't want him to marry her mother because she was part Native American.
Trump referred to Warren as "Pocahontas" at the rally, a derogatory reference to her controversial claims of Cherokee heritage. Todd again asked Warren.
While the senator said she never used her heritage claim to get ahead, she has been found listed as minority faculty in university directories. She is already running for re-election to the Senate in 2018.
The Massachusetts Democrat told CNN's Jim Acosta that she will not run for president in two years. "That is just fundamentally wrong".
Warren then said that "more than half of all native women have been the victims of sexual violence", and the "United States government does nothing about that".
"We need to bring some attention to it and we need to put some resources on it", she added.