"Harvey Weinstein isn't here tonight because, well, I've heard rumors he's insane and hard to work with", Meyers said. "It'll sound like that", Seth Meyers said, reported news agency PTI.
With sexual-misconduct allegations hovering over Hollywood for months, and nearly everyone dressed in black to support the Time's Up initiative opposing sexual harassment, the late-night host addressed the elephant in the room right when he came onstage Sunday night.
Meyers' words are especially pointed given the often loose, celebratory style of seasonal awards shows and how hosts can often whiff when attempting to strike at the establishment.
Watch Meyers' monologue up top.
Hollywood stars on Sunday donned all-black in solidarity with the anti-sexual harassment movement.
Meyers also took a shot at shunned actor Kevin Spacey. And to deliver the punch line to some of those jokes, Meyers even enlisted the help of some stars in the room, like Jessica Chastain.
Weinstein's name came up fairly early, with Meyers predicting that, years from now, he'll be booed after his death during the "In Memoriam" segment.
"Good evening ladies and remaining gentlemen", the Late Night host began. Just an incredibly attractive film, but I have to admit, when I first heard about a film where a naïve young woman falls in love with a disgusting sea monster, I thought, 'Oh man, not another Woody Allen movie'.
'It's been years that a white man in Hollywood was this nervous, ' he quipped.
Meyers joked about when Seth Rogen, rather than Trump, "was the guy making trouble with North Korea", referring to Rogen's movie "The Interview". "They're going to do another season of House of Cards? I hope he can do a Southern accent because Kevin Spacey sure couldn't". But those numbers might be off since a white person did the math. "They tried to get a woman to host this show, they really did". They said, "Hey, how would you like to come and be judged by some of the most powerful people in Hollywood?"
From there, the show moved on with Gal Gadot and Dwayne Johnson awarding Nicole Kidman with the first win of the night for best performance by an actress in a limited series or a motion picture made for television for her role on "Big Little Lies".
"We're all here tonight courtesy of the Hollywood Foreign Press". Quoth Meyers: "The only name that could make him angrier is the Hillary Mexico Salad Association". Meyers described Call Me By Your Name as a coming-of-age story for a young, queer man. Billy Eichner then cracked that Kevin Spacey said, "You lost me when you said 'of age'".