Free trade is especially popular among Davos attendees.
The meeting features some of the biggest elites in the world, where Trump's America First agenda will likely clash with a forum dedicated to economic globalism.
In a statement, Sarah Sanders, the White House press secretary, said: "The president welcomes opportunities to advance his America First agenda with world leaders", Sanders said.
Sitting presidents have rarely attended the event, held at a ski resort in the Swiss mountains, fearing its reputation for elitism may not play well politically at home.
This year's event will put Trump in the same room as numerous worldwide elites he attacked during his 2016 campaign.
President Donald Trump is heading to Davos for the world's most elite economic conference later this month
The White House said the billionaire would attend the Swiss gathering that's taking place days before his first State of the Union address in a Tuesday statement.
Trump goes to Davos after backing out of a Pacific Rim trade agreement and repudiating the Paris Climate accord.
This year's theme reflects the gathering's global flavor: "Creating a Shared Future in a Fractured World".
In an interview on Monday prior to the announcement, Harvard University professor Ken Rogoff identified Trump as a risk to the economic expansion. There's a randomness element that's hard to quantify. Davos is scheduled to be held January 23-26.
Executives at the conference will welcome Trump's corporate tax cut and the regulatory slash his administration had enforced.