Fourteen of them took a daily dosage of ibuprofen that many professional and amateur athletes take: 600 milligrams twice a day.
Before you go raid your medicine cabinet, Advil and Motrin are two brand names for ibuprofen.
At the end of the study, the men who took ibuprofen had developed compensated hypogonadism, a condition usually associated with smokers, elderly men and those with reproductive issues or physical disorders.
This is a problem, as the function of LH is to stimulate the production of testosterone, and not to significantly surpass testosterone levels.
Researchers came to this somewhat disturbing conclusion after splitting 31 male test subjects between the ages of 18 and 35 into two groups; they gave one group ibuprofen, and the other group a placebo. Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France, and a team of French and Danish researchers, began by exploring the health effects of pregnant women taking any of the 3 most common OTC pain relievers: acetaminophen, aspirin, and ibuprofen.
Men who take ibuprofen for longer than the bottle advises could be risking their fertility, according to a new study. "These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines".
The findings are certainly significant, as the 1,200mg of ibuprofen given to the participants each day is far below the suggested daily maximum of 3,200mg per day.
Ibuprofen belongs to a group of drugs called non-steroidal anti-inflammatories, or NSAIDs, that work by blocking the production of hormone-like signaling molecules called prostaglandins, which theoretically reduces pain and inflammation.
"The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human testis", the significance on the PNAS site reads. This is because the pituitary gland at the base of the brain had ramped up levels of another hormone that drives the production of extra testosterone.
Ibuprofen has also been linked to increased risk of heart attacks or stroke in those who take it long term.