Prime Minister Malcolm Turnbull has announced a long-awaited reshuffle of his cabinet team, naming a few virtual unknowns as ministers and surprisingly dumping a popular minister to the backbench.
Among the contenders to replace Senator Brandis as Attorney-General are Social Services Minister Christian Porter and Employment Minister Michaelia Cash.
Unveiling his new-look cabinet, Mr Turnbull announced two newly created portfolios.
There have been discussions about Mr Fletcher taking Communications Minister Mitch Fifield's job - and Senator Fifield taking over Social Services - as this would offer a chance to reset debate over the problem-plagued NBN, but such as change is considered unlikely.
Immigration Minister Peter Dutton will step up to become the Minister for Home Affairs - responsible for national security.
Also absent from the new line-up is Arthur Sinodinos, who has opted out of the federal cabinet while he undergoes cancer treatment.
But a major talking point has been the dumping of infrastructure minister Darren Chester, of the Nationals party.
"I just wish that the government would spend as much time worrying about the jobs of Australians as they spend worrying about the jobs of inconvenient cabinet ministers being shuffled off to appointments overseas", deputy opposition leader Tanya Plibersek told reporters in Sydney.
After more than a year of speculation, the ABC has confirmed Attorney-General George Brandis will leave Parliament to take up the post of Australia's High Commissioner to the United Kingdom.
The Prime Minister will also need to fill the outer ministry of Special Minister of State, which was recently vacated by now-Senate president Scott Ryan.
Senator Cash's significant promotion follows the October scandal that saw her media adviser David De Garis resign after admitting to alerting media to an AFP raid on the Australian Workers' Union.