He finished 17-for-25 for 205 yards.
In what had the makings of a competitive game early, the Patriots pulled away for a convincing 23-3 win over the Bills on Sunday.
Brady and McDaniels have worked together for more than a decade, including five seasons before the coordinator became the Denver Broncos' head coach in 2009 and more than five seasons afterward. Tight end Rob Gronkowski, whose late hit on Bills cornerback Tre'Davious White with the game well in hand in the fourth quarter may net him a fine or suspension, caught nine passes for 147 yards.
Arguably the only thing overshadowing the Bills lack of offense was the absence of quarterback Tyrod Taylor who went down with injury.
Reilly, in his first season with the Patriots after spending two with the Jets and one with the Dolphins, has appeared in four games this season and has a total of seven tackles (four solo, three assists).
Stephen Hauschka booted a 49-yard field goal as Buffalo trailed 9-3 at the half. Lawson was carted to the locker room in the third quarter with a knee injury. Going 70-yards in 10 plays the Patriots were able to extend their lead thanks to a Rex Bulkhead 1-yard touchdown run.
LeSean McCoy had 93 of the Bills' 183 rushing yards.
The 10-2 Patriots won their 14th successive road game - the second-longest streak in National Football League history - and reached double-digits in victories for the 15th consecutive season.
So the Patriots maintained possession and went on to kick a game-winning field goal.
That consistency will certainly be tested by New England's Tom Brady, who is not only second in the league in touchdown passes with 26, but has helped the Patriots log 10 touchdowns on their last 11 red zone drives.
This was Lee's second game with the Patriots. New England signed Lee, 23, off of Buffalo's practice squad on November 21. RT Cameron Fleming started in place of Marcus Cannon (ankle). Patriots CB Stephon Gilmore returned to Buffalo for the first time since leaving the team in free agency during the offseason.