The star received a standing ovation from the crowd at London's Eventim Apollo, and told them: I feel like I'm dreaming a little bit, this is incredible.
Sampha has won the 2017 Mercury Music Prize beating the likes of Stormzy and Ed Sheeran. Grime artist Stormzy had also been well-regarded, with his debut album Gang Signs & Prayer positioned to make it consecutive wins for grime artists following Skepta's win for Konnichiwa a year ago.
He dedicated the prize, which includes a cheque for £25,000 (about €28,000), to his parents, saying: "I had the best upbringing possible".
The event was hosted by Lauren Laverne; the award handed out by actor and DJ Idris Elba, who paid tribute to "an unbelievable array of artists".
Sampha - who joins recent Mercury laureates including the grime rapper Skepta, the experimental trio Young Fathers and the electronic musician James Blake - accepted the award with the kind of understated grace admirers have cited in his music.
Sampha has won the Mercury prize for 2017.
And this year the incredibly brilliant and extremely deserving Sampha took home the prize for "Process".
In the United Kingdom, there is no more prestigious award in music than the Mercury Prize.
The full list of odds are: 11/4 Glass Animals; 7/2 Kate Tempest; 7/2 Sampha; 11/2 J-Hus; 13/2 Loyle Carner; 7/1 Stormzy; 20/1 Alt-j; 20/1 Dinosaur; 20/1 The xx; 25/1 The Big Moon; 33/1 Blossoms; 33/1 Ed Sheeran. The Mercury Prize started out strong with Primal Scream's Screamadelica winning in 1992 and Suede's self-titled debut winning in 1993.